Crossref Medline Dec 28, 2021 · Antiarrhythmics
Feb 19, 2023 · The antiarrhythmic medications have typically been categorized according to the Vaughan-Williams (VW) classification system
However, some medications in this class also exert effects on Na Identify the mechanism of action of dofetilide
Amiodarone and dofetilide are the only two AAD that are currently approved for restoration of SR in AF with concomitant CHF and left ventricular (LV) dysfunction
Amiodarone is a potent antiarrhythmic agent that is used to treat ventricular arrhythmias and atrial fibrillation
Furthermore, backup pacing can prevent episodes
They found that amiodarone had superior efficacy in the prevention of AF associated with atrial tachycardia remodelling, compared to flecainide or dofetilide
Background Amiodarone causes less drug-induced torsade de pointes (TdP) compared to other class III antiarrhythmics
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It can be given by mouth
Common amiodarone side effects may include: nausea, vomiting, loss of appetite; or
Amiodarone side effects (more detail) In patients with heart failure, amiodarone and dofetilide are the only antiarrhythmic drugs that are proved to be safe, and they should be tried first
However, because of the risk of QT prolongation and ventricular arrhythmias sofosbuvir increases toxicity of amiodarone by unknown mechanism
18 The general time to onset of action of amiodarone after one dose given by the intravenous route is between 1 and 30 minutes, with therapeutic effects lasting from 1-3 hours
The risks of QT prolongation and TDP upon initiation are Amiodarone, quinidine, and dofetilide are AADs with numerous and clinically significant drug interactions
pulmonary fibrosis, thyroid and hepatic dysfunction), these agents are not suitable for all patients
Unlike amiodarone, dofetilide has little sinus, atrioventricular nodal, and His-Purkinje system effects
Whether patients with an implantable cardioverter-defibrillator (ICD) can be rapidly switched from amiodarone to dofetilide is not known
Amiodarone has multiple effects on myocardial depolarization and repolarization that make it an extremely effective antiarrhythmic drug
Anti-Arrhythmia Agents
Additive cardiac effects
Dofetilide is a class III antiarrhythmic drug commonly used for treatment of atrial fibrillation
For subsequent maintenance infusions, solutions containing a final amiodarone hydrochloride concentration of 1–6 mg/mL may be used