Keflex is a first-generation cephalosporin antibiotic
Younger than 15 years: 25-50 mg/kg/day orally divided every 6-8 hours for 10 days; not to exceed 4 g/day
vaginal itching or discharge
First-generation cephalosporins include cefazolin, cephalothin, cephapirin, cephradine, cefadroxil, and cephalexin
Cephalexin (also called Cefalexin) is a first generation cephalosporin antibiotic
Introduction Antibacterial; β-lactam antibiotic; first generation cephalosporin
Most cephalosporins start with cef, ceph, or kef
Capsule 250 mg 500 mg 750 mg (adult only) Oral suspension 125 mg/5mL 250 mg/5mL Tablet 125 mg (pediatric only) 250 mg 500 mg (adult only) Dosage Considerations –
Cephalexin is a semisynthetic first-generation cephalosporin antibiotic having methyl and beta-(2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem
Specifically it is
For instance, first-generation cephalosporins have narrow or limited spectrum than the third, fourth or fifth generation that has broader spectrum activity (Page 2007 )
If an oral cephalosporin used, 10-day regimen of first generation cephalosporin (cefadroxil, cephalexin) preferred instead of other cephalosporins with broader spectrums of activity (e
influenzae, and meningococci (often cause meningitis) (Barriere and Flaherty 1984)
clavulanic acid in amoxicillin-clavulanate (Augmentin) a bacterial gene encoding a penicillin-binding protein (PBP2a)
Skin and soft tissue infections (why is agent of choice before generalized symptoms) Cross-reactivity of PCN allergy <10%; 2nd Generation
Cephalothin, a first generation cephalosporin for parenteral use was the first cephalosporin to become available for patients in the US in 1964
Cephalexin is a semisynthetic first-generation cephalosporin antibiotic having methyl and beta- (2R)-2-amino-2-phenylacetamido groups at the 3- and 7- of the cephem skeleton, respectively
More recently, cefazolin, a first-generation cephalosporin, has been examined as a first line agent for treating MSSA infections, including bacteremia and endocarditis [21,34,35,36]
First-generation cephalosporins like Keflex are effective against many gram-positive bacteria, including Streptococcus and Staphylococcus species
temocillin, cephalexin
The third-generation class of cephalosporins is the most commonly prescribed group
Food and Drug Administration (FDA) in 1970 and is classified as a first-generation cephalosporin
Cephamycins are more active against anaerobes, such as
Cephalosporins are sometimes grouped into “generations” by their antimicrobial properties