Levaquin (levofloxacin) works by inhibiting two bacterial enzymes, topoisomerase IV and DNA gyrase, both of which are vital for the manufacture and repair of bacterial DNA and other DNA processes
This medicine is available only with your doctor's prescription
Two case reports have since documented an increase in INR in patients taking long-term warfarin on completion of levofloxacin therapy
Warfarin Warfarin is a blood thinner medication used to help prevent blood clots and stroke
You may report side effects to FDA at 1-800-FDA-1088
These adverse effects are seen commonly in patients receiving chronic warfarin therapy for clotting disorders and are
5, 8
Conflicting data exist regarding the clinical significance of this interaction
Similarly, no apparent effect of warfarin on levofloxacin absorption and disposition was observed
Warfarin (Coumadin, Jantoven) Theophylline (Theo-24, Elixophyllin) Diabetes medications, such as insulin and sulfonylureas
7 Digoxin 7
When starting or changing these drugs, INRs should be monitored closely; decreased doses of warfarin may be required